Assessment of von Willebrand Factor/ADAMTS13 Ratio and Vitamin K Levels as Predictor Markers for Severity of COVID-19 Patients

Objectives: To investigate the levels of each von Willebrand Factor, ADAMTS-13, and vitamin K in sera Iraqi patients infected with Covid-19 study association between them to explore mechanism roles micro thrombosis progression. Methods: In this case-control study, a total (60) COVID-19 (min-max) aged (35-65years) who presented within 7-12 days displaying symptoms were recruited. (30) apparently healthy persons same ages gender included as control group. divided into three groups: mild group (n=33), sever (n = 15), deceased 12). vWF, measured through enzyme-linked immunosorbent assays (ELISA) from volunteers group, moderate COVID-19, severe had COVID-19. Anthropometric, biochemical data analyzed. Results: The did differ significantly among groups. However, level vWF was higher cases groups compared indicating it be an independent predictor coronavirus disease. lower than especially case contrast, cases. /ADAMTS13 ratio at presentation died (26.14 vs 12.34; P < .0001). Linear regression analysis for revealed significant negative correlations vit. ,and positive d-dimer ferritin levels. However ADAMTS-13 demonstrated vit.K  in Conclusion: vWF-ADAMTS-l3 could help better define pathophysiology, clarify pathogenesis, improve prediction clinical prognosis, guide thromboprophylaxis treatment patients, which uses hall mark provide rational combined therapeutic approaches medical staff. A vWF/ADAMTS-13 prompt thrombolysed associated increased mortality morbidity.